Multistep microwave-assisted divergent synthesis of indolo-fused pyrazino-/diazepinoquinoxalinones on PEG support.

نویسندگان

  • Jin-Ji Lai
  • Deepak B Salunke
  • Chung-Ming Sun
چکیده

Synthesis of amino acid and indoline-substituted dinitrobenzene on a soluble polymer support (PEG) and its further reductive double-ring closure to afford structurally diverse indolo-fused pyrazino-/diazepinoquinoxalinones is described. Traceless synthesis of quinoxalinones coupled with application of the Pictet-Spengler-type condensation reaction furnished these novel scaffolds. These hitherto novel heterocycles are synthesized in shorter times under microwave irradiation conditions in comparison with that of classical reaction conditions.

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عنوان ژورنال:
  • Organic letters

دوره 12 10  شماره 

صفحات  -

تاریخ انتشار 2010